Tuesday, December 11, 2018

2018 Archive D

 Friday, December 21, 2018

La Traviata & La Bohème: Illness & Morality

As I am heading to the performance of La Traviata at the Met, I will reprint an earlier blog.

A reprint from Dec. 17 2013

La Traviata & La Bohème: Illness & Morality

In The Cockroach Catcher:


“It would not be a great surprise to anyone who has any inkling of the history of medicine that sooner or later any medical condition with an alleged aetiology of pure psychological origin will prove to have a non psychological cause. This is particularly true of those conditions classified by non-psychiatrists.

In the past, ignorance has led to belief that certain conditions are either punishment by god, visions of great religious significance or simply madness. Accordingly you might be burnt, become a saint or simply be given one of the psychiatric medications.”

Tuberculosis is one such condition that came to mind, more so as last Sunday we saw a production of La Traviata by one of opera’s grandest composers, Giuseppe Verdi.

In 1897, a young nun Thérèse Martin in a convent of Lisieux was dying of tuberculosis. She was essentially writing the equivalent of the modern day blog in the form of a diary. She was 24 then and had led an uneventful and sheltered life, taking the veil at only 15 and in contrast to most saints, she experienced and accomplished little. With her tuberculosis, her health deteriorated rapidly and she spent her last five years in the convent’s infirmary
, continuing to diarise her innermost thoughts and emotions up until her death. The convent published her writings as an autobiography: Story of a Soul. After her death, many miracles were attributed to her intervention. In 1925, she became Saint Thérèse of the Child Jesus and of the Holy Face, and during World War II, Pope Pius XII proclaimed her co-patron saint of France, along with Joan of Arc.

Yet not long before the Industrial Revolution, in folklore, tuberculosis had been regarded as vampirism. As people with TB often had red, swollen eyes, pale skin and coughing blood, stories abounded that the afflicted could only replenish this loss of blood by sucking blood.

All of this changed in the nineteenth century – Mimi in La Bohème, Violetta in La Traviata (from Murger’s Scènes de la vie de Bohème, and Alexander Dumas’ novel La dame aux Camélias) and of course Hugo’s Fantine in Les Misérables. Tuberculosis became the preferred cause of death for a certain type of female character.


Verdi at 38 began an affair with a singer who was later to become his wife. Many viewed La Traviata as Verdi’s own way of testing public opinion. His new wife was luckier than Violetta.

Verdi of course was an opera revolutionary and in a letter to his friend Cesarino de Sanctis early in 1853, he wrote, “For Venice I am writing La Dame aux Camélias, a contemporary subject. Another composer might not want to do it perhaps because of the costumes, the period, and a thousand other awkward scruples … But I am doing it with total pleasure. E
verybody screamed in horror when I suggested putting a hunchback on the stage. Well, I was happy to compose Rigoletto.”

He was not so lucky with Venice as they insisted on 1700 costume when Verdi wanted contemporary ones. In that production, Violetta was nowhere near consumptive although it might well be a reflection of sopranos of the time: big and fat.

Luckily for us, his threat to withdraw the opera completely was rescued by a second performance that fitted in with Verdi’s ideal and the opera world was blessed with one of the three most performed operas; La Boheme and Rigoletto being the other two. All three operas remain my favourites.

Carlos Kleiber’s Traviata starring Ileana Cotrubas and Placido Domingo has to be the all time best in my eyes (or more correctly to my ears), closely followed by Angela Gheorghiu’s amazing performance under Sir Georg Solti.
In 1993 we went to Boheme at the Met. A very beautiful and slim Mimi appeared and you could hear the silence in the audience as she started to sing. It was one of the best Boheme’s: Angela Gheorghiu’s debut at the Met.

Tuberculosis sells.
Opera in the end is still one of the best medium as Dumas is hardly known nor performed nowadays.


Friday, December 14, 2018

Learning from Nature: Chiton Brain & Eyes.

The Cockroach Catcher was on Cable Beach in Broome, Australia and found a creature he has never come across before and put the picture on Facebook. Luckily within a few minutes the answer came from his friend who generally knows most birds and plants. I raise my hat to him for knowing this: Chiton.




© 2018 Am Ang Zhang
I did some research and what I found was most interesting:

Chitons may be found mainly in the littoral surf zone. About 750 species of this primordial mollusc class are known today. The largest one is Cryptochiton stelleriwith 33 cm (about 14 in.), living on the American north western coast.
In colloquial language, chitons are also called coat-of-mail shells, their shell resembling the segmental armour on a knight's gauntlet, though, as we shall see later, the shell of a chiton is not segmented in the biological sense of the word.
Not only chitons' shells are hard. Chitons, like snails, possess a rasp tongue (radula), which they use to rasp food off the ground, if they are not among the few carnivorous species, such as Placiphorella rubra 

Then from OxfordThe Secrets Hiding in the Simplest Animal Brains

Chitons don’t have anything we’d generally consider to be heads, and it’s long been thought they don’t have brains, either, and instead sport a rudimentary, ladder-like nerve network. Sumner-Rooney and Sigwart argue in their paper that chitons aren’t really brainless, but rather have a brain that defies our expectations and understanding.

Then from Harvard: Creating a new vision for multifunctional materials.

Most eyes in nature are made of organic molecules. In contrast, the Chiton’s eyes are inorganic and made of the same crystalline mineral called aragonite that also assembles the body armor. They enable the Chiton to perceive changes in light and thus to respond to approaching predators by tightening their grip to surfaces under water.

Using a suite of highly resolving microscopic and crystallographic techniques, the team unraveled the 3-dimensional architecture and geometry of the eyes, complete with an outer cornea, a lens and an underlying chamber that houses the photoreceptive cells necessary to feed focused images to the Chiton’s nervous system. Importantly, the researchers found that aragonite crystals in the lens are larger than in the shell and organized into more regular alignments that allow light to be gathered and bundled.





The Cockroach Catcher on Amazon Kindle UKAmazon Kindle US







Thursday, October 25, 2018

Balicasag Island, Philippines.

9.5161° N, 123.6833° E













Ideas without precedent are generally looked upon with disfavour.
and men are shocked if their conceptions of an orderly world are challenged.
Bretz, J Harlen 1928.


We have always been led to believe that bleaching of the world's coral reefs is final proof of global warming. Not quite according to the NOAA:

When corals are stressed by changes in conditions such as temperature, light, or nutrients, they expel the symbiotic algae living in their tissues, causing them to turn completely white.

Warmer water temperatures can result in coral bleaching. When water is too warm, corals will expel the algae (zooxanthellae) living in their tissues causing the coral to turn completely white. This is called coral bleaching. When a coral bleaches, it is not dead. Corals can survive a bleaching event, but they are under more stress and are subject to mortality.

In 2005, the U.S. lost half of its coral reefs in the Caribbean in one year due to a massive bleaching event. The warm waters centered around the northern Antilles near the Virgin Islands and Puerto Rico expanded southward. Comparison of satellite data from the previous 20 years confirmed that thermal stress from the 2005 event was greater than the previous 20 years combined.

Not all bleaching events are due to warm water.

In January 2010, cold water temperatures in the Florida Keys caused a coral bleaching event that resulted in some coral death. Water temperatures dropped 12.06 degrees Fahrenheit lower than the typical temperatures observed at this time of year. Researchers will evaluate if this cold-stress event will make corals more susceptible to disease in the same way that warmer waters impact corals.

The Great Barrier Reef at 18.2871° S is hitting the news with much bleaching. 


Tioman Island vs The Great Barrier Reef!


Tuesday, October 9, 2018

NHS : World Class Medicine without trying!


Those doctors that grew up here may not know but those of us from overseas looked forward to coming for our specialist training in this country. A number of us went to the US and they did well too. There was little doubt that for many the years of training in the top hospitals here will guarantee them nice top jobs in Hong Kong or the rest of the commonwealth. 

Why?

We provided World Class Medicine without trying. A quote from a fellow blogger, Dr. No.


Dr No said...
Excellent post - and yes, that is exactly how it used to be. World class medicine without even trying - we just did it, because that is what we did, just as the dolphin swims, and the eagle soars. A key, even vital feature was that the doctors looking after their patients did not need to worry about money or managers. They just got on with it. There was no market to get in the way of truly integrated care. Some may point out that 13 year olds with teratomas are rare, and that is true, but what this case shows us, precisely because of its complexity, is just how capable the system was. And most of the time (of course not always), it dealt just as capably with more routine cases. "How is (sic) the new Consortia going to work out the funding and how are the three Foundation Trust Hospitals going to work out the costs." Exactly. And then: who is going to pay for the staff and their time to work out out all those costs and conduct the transactions?
What many politicians may not know is that pride in what we do is often more important than money or anything else. Our pride is one sure way to ensure quality of practice.

Do we really want to take that away now? Years of heartless re-organisation has left many of us dedicated doctors disillusioned. Many young ones have left. Poorly trained doctors that have no right to be practising medicine now even have jobs in some of these well known hospitals. 

Can we continue to practise World Class Medicine even if we wanted to?


Here is a reprint:

Tuesday, May 24, 2011





It is well known that we as doctors do not have all the answers and we can only base our diagnosis and treatment on current knowledge.


Patients or their relatives are used to trust the judgement of doctors and always hope for a better or even miraculous outcome. Their faith in their doctor is often supplemented by their own religious faith.


David Cameron is no different and he has stated so on record.


I am not here to analyse his faith.


I am here to re-tell one of the stories of hope and faith I have experienced as a very junior consultant in 1978:

The Mayo of the United Kingdom
The year was 1978 and I was employed by one of the fourteen Regional Health Authorities. The perceived wisdom was to allow consultants freedom from Area and District control that may not be of benefit to the NHS as a whole so the local Area or District Health did not hold our contracts. Even for matters like Annual Leave and Study Leave we dealt directly with RHA.


Referrals were accepted from GPs and we could refer to other specialists within the Region or to the any of the major London Centres of excellence. Many of us were trained by some of these centres and we respected them. They were the Mayos and Clevelands and Hopkins of the United Kingdom.  


Money or funding never came into it and we truly had a most integrated service.
We used to practice real, good and economical medicine.


The unusual cases:
Child Psychiatry like many other disciplines in medicine does not follow rules and do not function like supermarkets. Supermarkets have very advanced systems to track customer demands and they can maximise profit and keep cost down. In medicine we do sometimes get unusual cases that would have been a nightmare for the supermarket trained managers.

As it is so difficult to plan for the unusual it will become even more difficult if the present government had its way (and there is every sign that they will), not only will the reformed NHS find it difficult to cope with the unusual, it will find it extremely difficult to cope with emergencies.

Supermarket:
Why? These cases cost money and in the new world of Supermarket Styled NHS, they have to be dealt with! For that reason, not all NHS hospitals will be failed by Monitor. Some will need to be kept in order that someone could then deal with unprofitable cases. They will be the new fall guys.

But supermarkets can get things wrong too. In Spain after the Christmas of 2009 there were 4 million unsold hams.


©Am Ang Zhang 2010


Back to the patient:

Would my patient be dealt with in the same way in 2011?


     GP to Paediatrician: 13 year old with one stiff arm. Seen the same day.
     Paediatrician to me: ? Psychosis or even Catatonia. 
           Seen same day and admitted to Paediatric Ward, DGH.
     Child Psychiatrist to Gynaecologist: ? Pregnancy or tumour. Still the same day.
     Gynaecologist to Radiologist: Unlikely to be pregnant, ? Ovarian cyst.
     Radiologist (Hospital & no India based): Tell tale tooth: Teratoma.
     Gynaecologist: Operation on emergency basis with Paediatric Anaethetics Consultant. Still Day 1.
     Patient unconscious and transferred to GOS on same day. Seen by various Professors.
     Patient later transferred to Queen’s Square (National Hospital for Nervous Diseases), 
             Seen by more Professors.
     Regained consciousness after 23 days.
     Eventually transferred back to local Hospital.


None of the Doctor to Doctor decisions need to be referred to managers.


We did not have Admission Avoidance then. 

How is the new Consortia going to work out the funding and how are the three Foundation Trust Hospitals going to work out the costs.


The danger is that the patient may not even get to see the first Specialist: Paediatrician not to say the second one: me.


Not to mention the operation etc. and the transfer to the Centres of excellence.


Here is an extract from my book The Cockroach Catcher:  Chapter 29 The Power of Prayers
Just like Mayo Clinic:
“…….Mayo offers proof that when a like-minded group of doctors practice medicine to the very best of their ability—without worrying about the revenues they are bringing in for the hospital, the fees they are accumulating for themselves, or even whether the patient can pay—patients satisfaction is higher, physicians are happier, and the medical bills are lower.”
But it is probably too late:


          …………Something else was going on here, and I was not happy because I did not know what it was. I was supposed to know and I generally did. After all I was the consultant now.

          Thank goodness she could breathe without assistance. That was the first thing I noticed. I saw mother in the corner obviously in tears. She asked if her daughter would be all right. I cannot remember what I said but knowing myself I could not have said anything too discouraging. But then I knew I was in tricky territory and it was unlikely to be the territory of a child psychiatrist.

          A good doctor is one who is not afraid to ask for help but he must also know where to ask.

          “Get me Great Ormond Street.”

          “I already did.”

          She is going to be a good doctor.

          “Well, the Regional unit said that they had no beds so I thought I should ring up my classmate at GOS and she talked to her SR who said “send her in”.”

          Who needs consultants when juniors have that kind of network?  This girl will do well.

          “Everything has been set up. The ambulance will be here in about half an hour and if it is all right I would like to go with her.”

          “Yes, you do and thanks a lot.”

          I told mother that we were transferring her daughter to the best children’s hospital in England if not in the world and the doctor would stay with her in the ambulance. She would be fine.


“........Ten years later mother came to see my secretary and left a photo. It was a photo of her daughter and her new baby. She had been working at the local bank since she left school, met a very nice man and now she had a baby. Mother thought I might remember them and perhaps I would be pleased with the outcome. 

"I was very pleased for them too but I would hate for anyone to put faith or god to such a test too often."

David Cameron, if it was your plan not to have an integrated service, then there is not much we ordinary people could do except pray. If it was not your intention, then could you let us have an integrated service! That way you would not need many accountants and you will save money in doing so.




Pulse: GP consortium chairs are overwhelmingly opposed to any requirement to include hospital consultants on their boards, viewing it as a serious conflict of interest that would undermine the commissioning process, finds a Pulse survey.

King’s Fund: Million £ GP.

See also:

Wednesday, October 3, 2018

Autism: Challenges & Obstacles!



© 2012 Am Ang Zhang

 To me the meanest flower that blows can give
  Thoughts that do often lie too deep for tears.

OdeIntimations Of Immortality From Recollections Of Early Childhood.



Anthony

      One day a referral came of a boy called Anthony Wordsworth.  He had just turned three.
      “You will like Mrs Wordsworth.”  No reason was given. “Mr Wordsworth will probably not come to see you as he has a very important job in the City.  Anthony is such a handsome boy, a bit quiet, and I think you will like him too.”

      The Wordsworths lived in one of these big houses and Mrs Wordsworth looked very young for a mother with two children, the older one being nine. I marvelled some years later how with all the hard work her two children put her through she still managed to look that young. The wonders of modern make-up together with smart dresses might have deceived me.

      Anthony was truly autistic. At that time one of my juniors had just returned to work with me after having her twins.  She sat through the first session.
      She said to me afterwards, “I thought they did not make Kanner’s classics anymore.” Anthony was a Kanner’s Classic. Leo Kanner first described the classical autistic child in 1943 and there had not been a better description since. Not many children have all the classical symptoms, but one finds the diagnosis of Autistic Spectrum Disorder (ASD) more and more common place[1].
      I said, “Yes, even down to the good looks.” 

      I often wondered if our creator really has such a sense of humour or is everything just chance.

      One could not but feel sorry for the mother.  Later I found out that she came knowing that autism would be my diagnosis, and if I had come to anything different, I probably would have never seen her or Anthony again.
      She knew of the diagnosis from very tragic personal experience. Her own brother was diagnosed such in London by our very eminent Professor who was the world’s authority on autism.
      In other words, she had lived, breathed and dreamed autism all her life and now her worst nightmare was realised. Her own child had turned out to be autistic like her own brother. 

      Perhaps her years of looking after her brother had prepared her for this day. Perhaps our creator made sure that for those who were going to have difficult children, they were made tough enough. 

      Anthony’s older brother was smart and clever. She felt good then that perhaps genetics was not at play, and her worst fear was unfounded.

      I was once consulted by a grandmother on a very tragic situation. She had two daughters. One was severely autistic, and the other was very intelligent and a high achiever. The latter became an academic, married and received the best genetic counselling from the same university where she was a professor. Minimal chance, she was told. She went ahead and the first child was subsequently diagnosed as suffering from Retts Syndrome[2].  She was not really seeking any second opinion but wanted to know if Retts and Autism were the same.  This case reminded me of the old Yiddish saying “Men tracht un Got lacht” – If you want to make God laugh, tell him your plans.

      Anthony’s mother went on to tell me she was going to take matters into her own hands because she would not want her son to deteriorate like her own brother, who was thirty five then and living in an institution. 

      “Mrs Wordsworth, I belong to that small group of doctors who believe that the brain is really capable of a good deal more. But we have to give it the right input.” 

      This principle has been applied to the treatment of autism over the last fifteen years and the results are really quite exciting. We do not pretend to know the cause or causes of autism but I have been with some great pioneer workers and I believe that the old thinking that things cannot change is not entirely true.

      She started crying and Anthony came towards her.

      Even with the best breeding there was only so much one could hold back.
      It was a moving sight, more because Anthony moved towards mum. What a positive sign.

      “I would like to arrange for Anthony to see the same Professor that saw your brother. This is not because I do not trust my own diagnosis, but I think it may be what you would like but dare not request. It would be good for our future work together if you do go and see him.

      “Before the appointment which could be a while, there is something you can start if you are not doing already. Do not stop talking to Anthony. Give him running commentaries on what you are doing even if it is about tidying the place, getting his dinner or doing his laundry.”

      “Don’t wait for his response,” I emphasized.

      Many new parents tend to parent by responding to cues given to them. There is nothing wrong with that. We talk to our kids when they talk to us and we leave them alone if they want to play on their own. Sometimes parents insist that quiet play is actually good for their children when they themselves want some peace and quiet.

      With autistic children one may have to wait a very long time for those cues and they may never come.

      “To be honest, I have been doing quite a bit of that, but I was not sure if it was right or wrong and I never dare tell anyone, not even my husband.”

      It is always that much better to suggest something that a parent is already doing. First you are no longer instructing her and second you are more likely to succeed. She had been using her instinct and using it well. 
      She cried even more and told my secretary later that she was more moved because I seemed to know what she wanted and I saved her the embarrassment of having to ask me herself. She was planning to pluck up courage to ask me for a referral to the Professor towards the end of the session. It was not so much that she doubted my diagnosis but that she thought the Professor needed to know that there were now two cases in her family.

      Mrs Wordsworth did get her appointment pretty quickly. No surprises. The diagnosis was confirmed. The Professor thought some of my suggestions seemed interesting enough and Anthony would be best served attending the clinic locally. He was grateful for the update on her brother’s family history. He thought that Anthony’s major long term handicap would probably be his speech.

      With the Professor’s blessing, we could now start.

      We were aiming for very small changes but the feed would come from the parents and I wanted to get her husband involved if possible.
      “I told him everything after our first meeting. It’s a good job you referred us to London. I think he will be upset for a while but he will come round.”

      Denial is a useful if ineffectual defence, but now we needed to get results.   

      It was time to have something for show.
      “Do you think Anthony will have a speech impediment or handicap in that area?”
      “You’ve heard the Professor but we are not going to stop doing things just because problem was predicted. The best doctors do not mind being proved wrong now and again.”
      Mother produced a video tape.  A recording of a 90-minute period of her at home with Anthony.
      “At this rate he will speak before three and a half, don’t you think?” I joked.
      “Like my brother you mean.”  She has already told me that her brother had a serious speech problem.
      At three years and four months Anthony spoke. He did not just speak. He was in full sentences.
      I said to mother, you have delivered.

      Father came to see me the following session. I listened and picked out as many positive aspects as I could and encouraged him to just get on the floor and play with him. It was easy for me as I was already on the floor helping Anthony sort out a complex rail system that we had just acquired. 

      In our work, you sometimes just have to have fun. 

      One little boy once observed, “Do you live here, Dr Zhang? It must be fun, with so many toys to play with.”

      We worked on entrenchment and we worked on expectation. We also ventured into something newer – putting challenges and obstacles through play into Anthony’s life.

      Then we tried something even more daring – introducing imagination.



Steven

          About eight months after first seeing Anthony I had another full blown autism case referred to me at a different clinic.

          Steven was the younger of two brothers. His older brother had been a bit of a model child who never gave mother any trouble. Father was a pilot. Mother used to fly but had now switched to ground work. They had help at home.

          Mother realised that there was trouble when she found that Steven was counting lamp posts or rather reading the numbers on lamp posts. If for any reason she deviated from his normal route he would become very upset. Speech was otherwise minimal but he could read numbers from an early age, too early for mother to remember when.  One day he was counting as he was piling up building blocks, one of these early learning ones with alphabets on them.  He counted beyond twenty. But not much of anything else, no interest in colour, only numbers.

          He liked lining up his brother’s Dinky  cars. The main enjoyment was in the counting. One day the parents realised that it was the way the two brothers communicated and they felt his brother was responsible for helping him with the counting.

          But then reading the numbers – do we have a genius or what?

          The answer was we had a boy who suffered from autism.

          I tried to be frank and open with the parents, but I was probably a bit too frank for them. Both parents admitted later to the initial shock but felt that because I put it so confidently they might as well accept it. They said it would have been worse if I had suggested some tests to stall the time only to give them the diagnosis a week or two later. Those two weeks of “is he, is he not?” would have been more damaging.

          What helped them was my positive attitude towards the future and they could not wait to get started.

          One of Steven’s problems was coping with change and mother often had to endure two to three hours of crying until he fell asleep from the exhaustion, only to have him wake up two hour later to resume the crying. 
          By then I had developed various strategies and tactics with which I could bring the parents on board. Steven’s parents were exceptional, and they tried to come to appointments together, changing appointments if they clash with his flight schedule.
          We had been working hard on imaginary things – of fake cups of tea that was too hot or too sweet; of food that burnt the baby; and of the hurt when a child fell.  He was beginning to buy into a lot of that.
          Coming to the clinic still posed some problems for Steven. He found it difficult that the doctor needed to see someone else.  I was certainly responsible for his reluctance to leave. We had such fun together.
          One day both parents arrived with big grins on their face. They told my secretary Marjorie that I had to wait till the end of the session but they hoped it would work.
          I could hardly wait.
          “Steven, five minutes,” mother warned him as per usual practice.
          No response.
          “Two minutes.”
          No response.
          The suspense was killing me.
          “One minute.”
          Steven went over to his school bag. He took out something. I could not see what it was as it was imaginary. How stupid of me.
He put in two batteries. I could not see those either.
          With his other hand, he drew a big squarish thing in front of him that would have included most of me and my background. He aimed his thing and pressed.
          “Swish-swosh-swish .”
          “Ready. Mummy and daddy.”
          Steven had turned the session into a TV episode. He was now in control with his remote control. I was basically switched off.
          Two very proud parents walked off very swiftly with Steven in tow.
          “See you next time Marjorie,” Steven waved to my secretary. She approved. No crying from Steven.
          I was left standing there shell shocked.
          They have done it!

                                                                                 From the book, The Cockroach Catcher.    

Autism posts:

Autism: Somalis in Minnesota and Sunshine
Autism, the Brain and Tiger Woods
Autism and Money






Tuesday, October 2, 2018

Nuremberg & Thalidomide: The Good The Bad & The Ugly.

It is not really the first time we visited a place that has a rather haunting history. St. Petersburg is one such place especially when one re-visited the whole sordid saga of the murder of the small children of the Russian Tsar family.


Now we are starting our high school reunion on our river cruise. The journey starts at Nuremberg. All of us of course remember the Judgment at Nuremberg. I decided to watch it again. The principle that just because your boss told you to do things in a certain way did not absolve you from the greater humanitarian aspect of what you do. This is most important for doctors and if you think we have shied away from the Nuremberg era, think again. In one way or another, those that dare speak out against what management in our beloved NHS does were met with some of the worst fates unimaginable in any democratic society.

Nuremberg of course was the famous setting for one of Wagner’s well known Operas, Die Meistersinger von Nürnberg which was in 2011 performed at Glydnebourne for the first time ever to much international acclaim. 

But Nuremberg was sadly linked to one of the worst drugs disaster of our time. This was uncovered by none other than Newsweek.

As they opened a new Waitrose across from my clinic, I find myself shopping there most days after work. It was one of those de-roling activity that is important after a whole day being involved in the mad of sad world of child psychiatry. John Barnes in Swiss Cottage was the first local store that was very close to the Tavistock Clinic where I trained. It was there that I saw the wooden escalator that my father reminisce about of the ones in Shanghai in the 40s. John Lewis and Waitrose remained my favourite haunt for all these years.

One day, at one of the specially designed check outs, sat a girl on a special raised mechanical chair was a girl with arms a quarter the size of ours and a few minute fingers. Yes, a Thalidomide victim doing a proper check out job.

Yes, we tried our best not to notice and our best not to treat her any differently as we well know that that is what she would want. I raised my hat to Waitrose for treating her like any of their partners. That is how the world should be.

But I never knew that there was any link between Thalidomide and Nuremberg. O.K. I knew Thalidomide was developed by a German Company, Grünenthal.



Newsweek

Adding to the dark shadow over the company, it is increasingly clear that, in the immediate postwar years, a rogues’ gallery of wanted and convicted Nazis, mass murderers who had practiced their science in notorious death camps, ended up working at Grünenthal, some of them directly involved in the development of thalidomide.

 What they had to offer was knowledge and skills developed in experiments that no civilized society would ever condone. It was in this company of men, indifferent to suffering and believers in a wretched philosophy that life is cheap, that thalidomide was developed and produced.

Perhaps the best known of Grünenthal’s murderous employees was Otto Ambros. He had been one of the four inventors of the nerve gas sarin. Clearly a brilliant chemist, described as charismatic, even charming, he was Hitler’s adviser on chemical warfare and had direct access to the führer—and committed crimes on a grand scale. As a senior figure in IG Farben, the giant cartel of chemical and pharmaceutical companies involved in numerous war crimes, he set up a forced labor camp at Dyhernfurth to produce nerve gases before creating the monolithic Auschwitz-Monowitz chemical factory to make synthetic rubber and oil.

In 1948 Ambros was found guilty at Nuremberg of mass murder and enslavement and sentenced to eight years in prison. But four years later, he was set free to aid the Cold War research effort, which he did, working for J. Peter Grace, Dow Chemical, and theU.S. Army Chemical Corps. Ambros was the chairman of Grünenthal’s advisory committee at the time of the development of thalidomide and was on the board of the company when Contergan was being sold. Having covered up so much of his own past, he could bring his skills to bear in attempts to cover up the trail that led from the production of thalidomide back through its hasty trials to any origins it may have had in the death camps.



Dr. Kelsey is honored by President John F. Kennedy in 1962. (Courtesy of FDA)


The tragedy was largely averted in the United States, with much credit due to Frances Oldham Kelsey, a medical officer at the Food and Drug Administration in Washington, who raised concerns about thalidomide before its effects were conclusively known. For a critical 19-month period, she fastidiously blocked its approval while drug company officials maligned her as a bureaucratic nitpicker.

Freedom of Speech: Truth & Thalidomide!



Case 5 – The Truth about Thalidomide Given the lack of a constitution enshrining free speech, we do need some protection against frivolous libel actions and injunctions which try to prevent the truth from being revealed. Otherwise the truth about thalidomide would never have been told.

“Thirty-eight years ago,” he wrote, “I sat through days of hearings by the Law Lords deliberating on whether I and the paper I edited were guilty of contempt in 1972-3 in campaigning for justice for the thalidomide families. All five Law Lords voted to ban publication of our report. Only a 13-11 victory in the European Court of Human Rights removed the gag order” – and thus, I add, enabled The Sunday Times to expose one of the great scandals of that time, and subsequently win compensation for the families with young children born damaged or deformed, often without legs or arms, because their mothers had taken the drug, thalidomide, which was marketed as a mild sedative that would relieve morning sickness in pregnancy.                                                                                             Telegraph

Luckily, the 
European Court eventually ruled for The Sunday Times:

“The newspaper then decided to fight the injunction on its investigation into the origins and testing of the drug. The case went right through the British legal system and up to the European Court of Human Rights, which decided that the injunction violated the right of ‘freedom of expression’. The full story of thalidomide could eventually be told in 1976, revealing that both Grünenthal (the maker) and Distillers had not met the basic testing requirements of the time.”



I mentioned thalidomide also because in 2002 Gordon Brown, the then chancellor, attempted to tax the benefits payable through the Thalidomide Trust.

Friday, September 14, 2018

NHS & The Elite: Community & Specialist Hospitals!

In Hong Kong, we do not have State funded GP services but there are State funded public hospitals where you get top quality treatments. In Singapore, public hospitals are not free but the poor that are on Social Security will have their fees waived. Singapore public hospitals are so well run that most prefer to go to them for major illnesses. 


                                                                                           

Singapore Health Care: Best Public Hospitals!


The truth is that medical tourists do not come for the 
GP services 
we provide, they come 
for 
the cutting edge medical procedures.


The Elite

Zebra in fact belongs to the same family as the horse (Genus Equus) but unlike the horse has never been domesticated. It is believed that the stripes in a herd is protective as many animals merge together and thus appeared larger.     


There is now a new plot on the horizon: Persuade people that they only need community hospitals near them to be run by Primary Care and they may not even be doctors.

 

This way the punters might be tricked into not going to Hospital A&Es but Urgent Care Centres at these locals.

 

Really.

 

Punters would not be punters if they are that stupid.

 


No matter; as we will close A&Es and even their hospitals.

 

Why?

 

It is the one big drain on NHS spending and it cannot be controlled. We can pay GPs if they do not refer but self referrals to A&E is now the norm.

 

A reprint:

NHS Reform: Democracy is for the Elite! So is Health Care!

Is it really that difficult to grasp! Our democracy is for the ELITE. Why pretend? So is Health Care!


Most people in well paid jobs (including those at the GMC) have health insurance. GPs have traditionally been gatekeepers and asked for specialist help when needed. If we are honest about private insurance it is not about Primary Care, that most of us have quick access to; it is about Specialist Care, from IVF to Caesarian Section ( and there are no Nurse Specialists doing that yet), from Appendectomy to Colonic Cancer treatment (and Bare Foot doctors in the Mao era cannot do the latter either), from keyhole knee work for Cricketers to full hip-replacements, from Stents to Heart Transplants, from Anorexia Nervosa to Schizophrenia, from Trigeminal Neuralgia to Multifocal Glioma, from prostate cancer to kidney transplant and I could go on and on.China realised in 1986 you need well trained Specialists to do those. We do not seem to learn from the mistakes of others.

When there are not enough specialists to go round in any country money is used to ration care.


So we are going to but in a peculiar manner as the NHS used to be state run and free. Reform is needed!!! Enter GP commissioning. If it is your GP doing the rationing it is no longer the State's problem.
Some very clever people indeed are working for the government. 


Is it Conspiracy or Cockup? You decide.

But strangely they thought there is still money to be made.

The current concern for the NHS Reform is perhaps too focused on privatisation.

The main aim by some very clever people in government is that somehow there must be a way to limit health spending.

The first obvious way is to find someone that could do it without the blame coming back to the politicians who needs to worry about the next election or next job.

GP Commissioning was thought to be the answer as the blame would now be on the GPs.

Integration of Health Care
Integration of Health Care now carries a new meaning: integrated as long as it is all within the remit of Primary Care and not between Primary and Secondary Care. Yet there is only so much that Primary Care can do unless they started employing their own consultants and running there specialist hospitals. That is one way of saving money.

The other way is to refer to Any Qualified Provider, the new NHS speak for Private Providers. Better still if these are owned by the same organisations that own some of the GP practices. Believe me, it is already happening and it will spread.

How could this be done? Simple, NHS Foundation Hospitals will not stand a chance if they have to continue with the expensive and unprofitable conditions or expensive dialysis and Intensive Care that many private insurers will not touch. In the new world order, they will fail and be closed or be bought by private companies. We have the regulator called Monitor that will see to it.

Again it will not be the politician’s fault: just bad management.

The new structure of HSCB is perfectly geared towards failing FT Hospitals. Some will survive through high levels of private work for those from wealthy countries. There is only a limited number of specialists to go round in England and in fact in most countries.

Which means that there will be a long waiting list for NHS patients!!!

Rationing by any other name.

                                                                       All photos ©2012 Am Ang Zhang

It really does not need a genius to work out that Foundation Hospitals if they fail will be bought up by private firms.

 

So there are not enough Consultants and shortage creates demand and you can name your price. Consultants do not really want to waste time in consortia arguing about the price of hips or knees. 

 

Privateers

A big portion of the NHS money will now be spent in the counting houses of the new Commissioning Offices. Gradually more and more of that money will be re-distributed to Privateers.

 

Those who could afford to will now get their own Health Insurance and when the Insurers refuse to cover some conditions you may have to return to the NHS. But who knows, it might just be too late then as those hospitals may no longer be there

So do you really think that hospitals are not necessary, or not necessary for the average citizen of England. Soon they will be sold and it will be costly to buy them back.

What about medical training? If these hospitals are sold, who pays?

And watch out, someone, your parent, your spouse, your child and even your MP may need a Hospital Consultant one day. 

Do we still have those: yes we do!  See here>>>>
In London alone these are specialist hospitals that are famous the world over:
The Maudsley Hospital

Then there is Papworth. Need I say more!!!
I know that when you visit them nowadays, these places seem to be full of: non locals. Or could it be that these are now the new locals, I doubt as you can sometimes see the lovely foreign plated cars parked outside them. If I am wrong, I do apologise.
The truth is that medical tourists come not for the GP services we provide, they come for the cutting edge medical procedures and in England, it is also about value for money.'

So, opening up many of these rather precious hospitals for up to 49% private will mean a severe reduction in actual medical times available to NHS patients.

That is why: the pretending is over. No, at the end of the day it will not be the medical care you can get from your GP or Noctors, it will be well trained specialists with up to date complex procedures that you or one of your relatives may need!

Wednesday, September 12, 2018

Save the NHS: Control Health Insurers!

Government can have the power to control Health Insurers thus allowing those that like to have free Cappuccinos when waiting for their Medical Consultation. And make sure if the Privateers mess up and NHS had to take over, they pay. 




It must be very obvious that all the talk about medical cover for visitors to England never mention the need for health insurance.

Could this be because insurers have managed not to cover for everything. One need to ask the question on how one ever travel to the US where cost of medical care is extremely high.

It may well be prudent for government to insist that non EU visitors to this country must have mandatory Health Insurance as part of the admission requirement. This should apply to students and tourists alike. After all nobody in their right mind would dream of going to the US without proper insurance.

We have managed to get people to insure their cars, why not their bodies.

There is of course the need to fully control Health Insurers for those that live in England if they want cover. 

Let people opt out of the NHS if it is so bad! But Insurers need to cover every thing. 

Citizens could be given a tax break and yet have the insurance policy incorporated into their NI/NHS number so that those with the tax break, the insurer will be charged for every kind of medical care they receive if they were within the NHS.


©1994 Am Ang Zhang

If we are not careful Private Insurance will creep into England without a single bit of control as it is singularly important to stop Insurers to reject those with pre-existing conditions or dump them once they have a chronic illness such as Type 1 Diabetes. 

Patients could have to start to pay charges to use basic NHS services such as GPs because the health service’s finances have become so dire, the leader of Britain’s doctors has warned. 
Dr Mark Porter, the head of the British Medical Association (BMA), said that whoever takes office after the general election will inevitably be tempted to bring in charges and may not be deterred by the unpopularity of such a seismic change to the health service.
....“You say it’s politically toxic. It’s not, really, is it? Look at dentistry and look at social care. They carry with them exactly the same offer to the public by which the NHS was set up; that we will remove from you – this society, us acting collectively – the terrible fear of bankrupting yourself by having an illness, by needing healthcare.
“And yet we allow people to be bankrupted by social care and we allow people to be deterred from seeking dental care because of charges,” Porter said.
Can we think of ways round this?
There is little doubt that a system based on insurance will need smart legislation to control the insurers. If the NHS is going to make use of wealthier individuals to use Health Insurance, then the same smart laws will need to be enacted for the regulation of Insurers. We should have learnt through the banking failures that in business, there is no such thing as self regulation.


Here are some things the law will do:
·         It will prohibit insurance companies from refusing to sell coverage to people simply because they have one or more pre-existing conditions.
·         It will also prohibit them from cancelling our coverage when we get sick just to avoid paying for our care.
·         It will prohibit insurers from charging women more than men for comparable coverage and will not allow them to charge older folks more than three times as much as younger folks.
·         It will require them to spend at least 80 percent of what we pay in premiums actually paying claims and improving care.
·         It will allow young adults—who comprise the largest segment of the uninsured—to stay on their parents’ policies until age 26.

 

Summary of a popular post:

·                     Ends discrimination against people with pre-existing conditions.
·                     Limits premium spread to normal, high risk and healthy risk to say under 20% either way of normal.
·                     Limits premium discrimination based on gender and age.
·                     Prevents insurance companies from dropping coverage when people are sick and need it most.
·                     Caps out-of-pocket expenses so people don’t go broke when they get sick.
·                     Eliminates extra charges for preventive care.
·                     Contribute to an ABTA style cover in case Insurance Companies go bust and many might.

We could legislate that Insurers will have to pay for any NHS treatment for those covered by them. It will stop Insurers “gaming” NHS hospitals. This will prevent them saving on costly dialysis and Intensive Care. Legislate for full disclosure of Insured status.

Insurers cannot drop coverage or treatment after a set period and even if they do they will still be charged if the patient is transferred to an NHS Hospital.

This will eliminate problems like PIP breast implants.

It will indeed encourage those that could afford it to buy insurance and in any case most firms offer insurance for their employees including the GMC.

To prevent gaming of Insurers by individual patients (I look after their interest too), the medical fee should be paid up front by the patient and then deduction taken from premiums. Corporate clients like those with the GMC should not be gaming Insurers.

Imagine the situation where those with “individual personalised budget” being able to “buy” their own insurance!

In fact, to save money, government can buy insurance for the mental patients and the chronically ill.

This way there will be real choice and insurers will be competing with each other to provide the worst deal.

Why?

What Health Insurer will want the business? 


Perhaps they will go back to the US and we will have our own NHS back.                                                                            
The Cockroach Catcher on Amazon Kindle UKAmazon Kindle US





[1] Diagnosis of Autism Spectrum Disorder - There is a belief that Kanner’s criteria remained the strictest, though other advocates for government funding of provisions for Autistics argue otherwise. Doctors can no longer rely on “clean” data.

[2] Retts Syndrome - Andreas Rett first described the syndrome in 1965, first thought to be a severe form of Autism now known to be related to MECP2 mutation.

Wednesday, December 5, 2018

Holidays Are for Counting WSJ






Arithmetic progressions, like the candles of Hanukkah or the gifts of ‘The Twelve Days of Christmas,’ can be powerful tools in number theory



ILLUSTRATION: TOMASZ WALENTA



By 

Eugenia Cheng

Dec. 5, 2018 10:28 a.m. ET

This week Jews around the world are lighting candles in eight-branched menorahs (with one “attendant” candle to light the others) to celebrate the festival of Hanukkah. As a symbol of the miracle of one night’s worth of oil giving light for eight days, the candles are lighted in sequence with one candle on the first night, two on the second and so on until the final night.

In mathematics, this is called an arithmetic progression—a sequence in which the numbers increase by the same amount at each step. This contrasts with a geometric progression, in which the numbers are successively multiplied by the same amount and grow exponentially. Arithmetic progressions grow slowly and steadily, which might seem boring, but they have far-reaching interest in pure mathematics.

Arithmetic progressions are involved in the study of prime numbers, the elusive building blocks of number theory. A celebrated theorem proved by Ben Green and Terence Tao in 2004 shows that the sequence of prime numbers—numbers with exactly two factors, one and the number itself—contains arithmetic progressions of unlimited length. The sequence 3, 5, 7, where the numbers increase by 2, has a length of 3, but it doesn’t go any further since the next number in the progression would be 9, which isn’t prime. To get a progression of prime numbers with a length of 10 we have to go up to 199, 409, 619, and so on, which has increments of 210.

The existence of longer and longer progressions is surprising, because the prime numbers generally get more and more spaced out as they get bigger. Exactly how the prime numbers are distributed is notoriously difficult to pin down, though mathematicians have been trying for centuries.

A more straightforward process involving arithmetic progressions is simply to add up the numbers. Soon we’ll hear everywhere “The Twelve Days of Christmas,” the song involving more gifts every day until on the 12th day we have 12 drummers drumming, 11 pipers piping and so on, all the way down to yet another partridge in a pear tree. How many total gifts do we end up with?

The numbers are quite small, so we can add them up fairly easily: 1+2+3+4, etc. But if the numbers were larger or the sequence longer, a small trick would help. We could write out the numbers 1 to 12 in a row and then write the same numbers in a row underneath them but backward, so that 12 will be under 1, 11 will be under 2 and so on.

Each vertical pair of numbers, it turns out, adds up to the same thing: 13. There are 12 columns, so the total of all the numbers we’ve written down must be 12x13=156. Because we wrote down our list of numbers twice, the total we want is half of 156, that is, 78.

At one level this is just a neat trick for adding up a list of numbers, but it also gives a taste of the field of combinatorics, which deals with combinations of objects in different configurations, including shapes, connected networks and codes. It often involves flipping the way we think about something in order to do surprisingly efficient reasoning. Seeing the trick of adding up arithmetic progressions is one of the first things that attracted me to math when I was a child.

As for the application of arithmetic progressions to prime numbers, life can go on if we don’t understand exactly how the prime numbers are distributed. But the mathematician’s urge is to understand the logical core of everything around us, especially the things that are basic on the surface but mysterious deep down.

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